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Photoacoustic Detection and Optical Spectroscopy of High-Intensity Focused Ultrasound-Induced Thermal Lesions in Biologic Tissue

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posted on 23.05.2021, 11:32 by Mosa Alhamami
In this study, the capability of a photoacoustic (PA) method in detecting high-intensity focused ultrasound (HIFU) thermal lesions was investigated in chicken breast tissue in vitro and the optical properties of the HIFU-treated and native tissues were determined. Created with a 1-MHz HIFU transducer, the detectability of the induced thermal lesions was assessed photoacoustically at 720 and 845 nm and their optical properties were characterized in the wavelength range 500-900 nm. The results show that the averaged ratio of the peak-to-peak PA signal amplitude of HIFU-treated tissue to that of native tissue is more than 3 fold. The optical spectroscopy investigation revealed that the absorption and reduced scattering coefficients are higher for HIFU-treated tissues than native tissues. This work demonstrates the capability of the PA method in detecting HIFU-induced thermal lesions due, in part, to the increase in their optical absorption coefficient, reduced scattering coefficient, and deposited laser energy fluence.





Master of Science


Biomedical Physics

Granting Institution

Ryerson University

LAC Thesis Type